E-ISSN 2367-699X | ISSN 2367-7414
 

Original Article 


The Correlation Between Ulcerative Colitis Activity and Vitamin D

Mehmet Nur Kaya, Ayla Yıldız.

Abstract
Objective: One of the most important indicators of platelet reactivity is the mean platelet volume. The platelet distribution width showing the heterogeneity of the platelet volume is a sign of platelet activation. In our study, we aim to show the correlation between ulcerative colitis activity and vitamin D, the platelet distribution width, mean platelet volume. Methods: The Truelove and Witts' severity index was used to determine ulcerative colitis activity. In accordance with the guidelines, serum 25-OH vitamin D levels of >30 ng/ml were considered as sufficient vitamin D, 20-30 ng/ml as vitamin D insufficiency, <20 ng/ml as vitamin D deficiency, and <10 ng/ml as severe vitamin D deficiency. Results: Patients with severe ulcerative colitis activity, 10% had vitamin D deficiency and 90% had severe vitamin D deficiency (p<0.001). The patients with mild ulcerative colitis activity had the highest mean platelet volume (9.5±0.44), while the patients with severe ulcerative colitis activity had the lowest mean mean platelet volume (7.1±1.52) (p<0.001). Likewise, the patients with mild ulcerative colitis activity had the highest mean platelet distribution width (17.9±1.04), while the patients with severe ulcerative colitis activity had the lowest mean platelet distribution width (14.8±2.04) (p<0.001). Conclusion: This study with a high level of evidence supports that 25-OH vitamin D has an anti-inflammatory effect in inflammatory diseases and that 25-OH vitamin D levels decrease as the disease activity increases. Moreover, the negative correlation between ulcerative colitis activity and mean platelet volume, platelet distribution width is demonstrated.

Key words: Ulcerative colitis, Vitamin D, Mean platelet volume, Platelet distribution width


 
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Pubmed Style

Kaya MN, Yildiz A. The Correlation Between Ulcerative Colitis Activity and Vitamin D. doi:10.5455/ijsm.2020-05-027


Web Style

Kaya MN, Yildiz A. The Correlation Between Ulcerative Colitis Activity and Vitamin D. http://www.ejos.org/?mno=106639 [Access: November 20, 2020]. doi:10.5455/ijsm.2020-05-027


AMA (American Medical Association) Style

Kaya MN, Yildiz A. The Correlation Between Ulcerative Colitis Activity and Vitamin D. doi:10.5455/ijsm.2020-05-027



Vancouver/ICMJE Style

Kaya MN, Yildiz A. The Correlation Between Ulcerative Colitis Activity and Vitamin D. doi:10.5455/ijsm.2020-05-027



Harvard Style

Kaya, M. N. & Yildiz, . A. (2020) The Correlation Between Ulcerative Colitis Activity and Vitamin D. doi:10.5455/ijsm.2020-05-027



Turabian Style

Kaya, Mehmet Nur, and Ayla Yildiz. 2020. The Correlation Between Ulcerative Colitis Activity and Vitamin D. doi:10.5455/ijsm.2020-05-027



Chicago Style

Kaya, Mehmet Nur, and Ayla Yildiz. "The Correlation Between Ulcerative Colitis Activity and Vitamin D." doi:10.5455/ijsm.2020-05-027



MLA (The Modern Language Association) Style

Kaya, Mehmet Nur, and Ayla Yildiz. "The Correlation Between Ulcerative Colitis Activity and Vitamin D." doi:10.5455/ijsm.2020-05-027



APA (American Psychological Association) Style

Kaya, M. N. & Yildiz, . A. (2020) The Correlation Between Ulcerative Colitis Activity and Vitamin D. doi:10.5455/ijsm.2020-05-027