E-ISSN 2367-699X | ISSN 2367-7414
 

Original Research 


Prophylactic antibiotics in high risk patients undergoing laparoscopic cholecystectomy.

Anil Negi, Dhiraj Kumar, Sudesh Kumar Sagar, Himanshu Singh, Astha Yadav, Durgesh Kumar Pal, Vishwanath Pratap Singh, Akshita Gupta, Sagar Mittal.

Abstract
Introduction: The Centers for Disease Control and Prevention (CDC) recommends the administration of a single dose of prophylactic antibiotics in patients undergoing clean-contaminated surgeries.
Aim: The current study was done to compare outcomes in high-risk patients undergoing Laparoscopic cholecystectomy between those who received and those who did not receive prophylactic antibiotics in the pre-operative period.
Patients and Methods: It was a randomized controlled trial done in the Department of General Surgery of a tertiary care teaching hospital over the period of 24 months (January 2018-December 2019), after approval by the Institutional Ethics committee. Patient admitted for Laparoscopic cholecystectomy were randomized into two groups A (who did not receive prophylactic antibiotics) and B (those who received antibiotics). Data were recorded in a pre-designed, standardized data collection proforma and analyzed using the statistical software SPSS version 18.0. Means were calculated for continuous variables, the frequency was calculated for discrete variables and other analyses were done using the statistical software.
Results: A total of 216 patients were included with Group A and B included 99 and 117 patients respectively with similar baseline demographic characteristics and pre-operative indications for cholecystectomy. Surgical site infection occurred in four and three patients in the study and control group respectively. All Surgical site infections were superficial and responded to conservative management only. None of the infected patients required intravenous therapy or hospitalization. The mean duration of hospital stay in patients not having received prophylactic antibiotics (Group A) approached significance (p=0.07) though the range (in days) was the same in both the groups.
Conclusions: Prophylactic antibiotics play no role in the prevention of surgical site infection in patients at high risk, undergoing laparoscopic cholecystectomy. The key to preventing postoperative infection lies in the aseptic minimally invasive operation and the necessary peritoneal lavage and drainage during LC.

Key words: Laparoscopic cholecystectomy, high risk, antibiotics prophylaxsis


 
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How to Cite this Article
Pubmed Style

Negi A, Kumar D, Sagar SK, Singh H, Yadav A, Pal DK, Singh VP, Gupta A, Mittal S. Prophylactic antibiotics in high risk patients undergoing laparoscopic cholecystectomy.. Int J Surg Med. 2021; 7(1): 24-30. doi:10.5455/ijsm.laparoscopic-cholecystectomy-antibiotics


Web Style

Negi A, Kumar D, Sagar SK, Singh H, Yadav A, Pal DK, Singh VP, Gupta A, Mittal S. Prophylactic antibiotics in high risk patients undergoing laparoscopic cholecystectomy.. http://www.ejos.org/?mno=121970 [Access: March 03, 2021]. doi:10.5455/ijsm.laparoscopic-cholecystectomy-antibiotics


AMA (American Medical Association) Style

Negi A, Kumar D, Sagar SK, Singh H, Yadav A, Pal DK, Singh VP, Gupta A, Mittal S. Prophylactic antibiotics in high risk patients undergoing laparoscopic cholecystectomy.. Int J Surg Med. 2021; 7(1): 24-30. doi:10.5455/ijsm.laparoscopic-cholecystectomy-antibiotics



Vancouver/ICMJE Style

Negi A, Kumar D, Sagar SK, Singh H, Yadav A, Pal DK, Singh VP, Gupta A, Mittal S. Prophylactic antibiotics in high risk patients undergoing laparoscopic cholecystectomy.. Int J Surg Med. (2021), [cited March 03, 2021]; 7(1): 24-30. doi:10.5455/ijsm.laparoscopic-cholecystectomy-antibiotics



Harvard Style

Negi, A., Kumar, . D., Sagar, . S. K., Singh, . H., Yadav, . A., Pal, . D. K., Singh, . V. P., Gupta, . A. & Mittal, . S. (2021) Prophylactic antibiotics in high risk patients undergoing laparoscopic cholecystectomy.. Int J Surg Med, 7 (1), 24-30. doi:10.5455/ijsm.laparoscopic-cholecystectomy-antibiotics



Turabian Style

Negi, Anil, Dhiraj Kumar, Sudesh Kumar Sagar, Himanshu Singh, Astha Yadav, Durgesh Kumar Pal, Vishwanath Pratap Singh, Akshita Gupta, and Sagar Mittal. 2021. Prophylactic antibiotics in high risk patients undergoing laparoscopic cholecystectomy.. International Journal of Surgery and Medicine, 7 (1), 24-30. doi:10.5455/ijsm.laparoscopic-cholecystectomy-antibiotics



Chicago Style

Negi, Anil, Dhiraj Kumar, Sudesh Kumar Sagar, Himanshu Singh, Astha Yadav, Durgesh Kumar Pal, Vishwanath Pratap Singh, Akshita Gupta, and Sagar Mittal. "Prophylactic antibiotics in high risk patients undergoing laparoscopic cholecystectomy.." International Journal of Surgery and Medicine 7 (2021), 24-30. doi:10.5455/ijsm.laparoscopic-cholecystectomy-antibiotics



MLA (The Modern Language Association) Style

Negi, Anil, Dhiraj Kumar, Sudesh Kumar Sagar, Himanshu Singh, Astha Yadav, Durgesh Kumar Pal, Vishwanath Pratap Singh, Akshita Gupta, and Sagar Mittal. "Prophylactic antibiotics in high risk patients undergoing laparoscopic cholecystectomy.." International Journal of Surgery and Medicine 7.1 (2021), 24-30. Print. doi:10.5455/ijsm.laparoscopic-cholecystectomy-antibiotics



APA (American Psychological Association) Style

Negi, A., Kumar, . D., Sagar, . S. K., Singh, . H., Yadav, . A., Pal, . D. K., Singh, . V. P., Gupta, . A. & Mittal, . S. (2021) Prophylactic antibiotics in high risk patients undergoing laparoscopic cholecystectomy.. International Journal of Surgery and Medicine, 7 (1), 24-30. doi:10.5455/ijsm.laparoscopic-cholecystectomy-antibiotics