E-ISSN 2367-699X | ISSN 2367-7414
 

Original Research 


Correlation between vascular endothelial growth factor-a serum with clinical stage, histopathologic grading and estrogen receptor status breast cancer patient in Makassar

Indra, Daniel Sampepajung Sampepajung, Haryasena, Muhammad Faruk.

Abstract
Objective: Breast cancer ranks first as the leading cause of female mortality, with an estimated 100,000 person each year. One of the pathogenesis ways of breast cancer is angiogenesis, which is characterized by overexpression of vascular endothelial growth factor (VEGF).
Methods: This research was conducted involving 42 patients with breast cancer who had no history of other illnesses. In this study, the serum is used to determine blood levels of VEGF in a quantitative and in-depth interview.
Result: The results of examining serum VEGF ELISA's lowest value obtained were 34.1 pg/ml while the highest value was 3028.2 pg/ml. Of the 42 samples studied showed that the value of serum VEGF cut of point just below the EBC as much as 11.9% and 33.3% whereas LABC cut of point just above the LABC and MBC respectively 59.5% and 28.6 % with p <0.001. For histopathological grading, showed that serum VEGF for value above cut off point only at moderate grade high as 19% and as much as 35.7% while the value of serum VEGF undercut of a point on a low grade as much as 21.4%, moderate 16.7 % and a high of 7.1%, p <0.001. Also found, patients with estrogen receptor-positive amounted to 57.2% with VEGF values above and below the cut-off point, respectively of 28.
Conclusion: There is a correlation between VEGF-A serum values and clinical breast cancer stage and histopathologic grading breast cancer patients, but there is no correlation between VEGF-A serum values and breast cancer estrogen receptor status.

Key words: Breast cancer, VEGF, Prognostic factors


 
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How to Cite this Article
Pubmed Style

, Sampepajung DS, Haryasena , Faruk M. Correlation between vascular endothelial growth factor-a serum with clinical stage, histopathologic grading and estrogen receptor status breast cancer patient in Makassar. Int J Surg Med. 2021; 7(1): 44-48. doi:10.5455/ijsm.vegf-a-breast-cancer


Web Style

, Sampepajung DS, Haryasena , Faruk M. Correlation between vascular endothelial growth factor-a serum with clinical stage, histopathologic grading and estrogen receptor status breast cancer patient in Makassar. http://www.ejos.org/?mno=63147 [Access: March 03, 2021]. doi:10.5455/ijsm.vegf-a-breast-cancer


AMA (American Medical Association) Style

, Sampepajung DS, Haryasena , Faruk M. Correlation between vascular endothelial growth factor-a serum with clinical stage, histopathologic grading and estrogen receptor status breast cancer patient in Makassar. Int J Surg Med. 2021; 7(1): 44-48. doi:10.5455/ijsm.vegf-a-breast-cancer



Vancouver/ICMJE Style

, Sampepajung DS, Haryasena , Faruk M. Correlation between vascular endothelial growth factor-a serum with clinical stage, histopathologic grading and estrogen receptor status breast cancer patient in Makassar. Int J Surg Med. (2021), [cited March 03, 2021]; 7(1): 44-48. doi:10.5455/ijsm.vegf-a-breast-cancer



Harvard Style

, Sampepajung, . D. S., Haryasena, . & Faruk, . M. (2021) Correlation between vascular endothelial growth factor-a serum with clinical stage, histopathologic grading and estrogen receptor status breast cancer patient in Makassar. Int J Surg Med, 7 (1), 44-48. doi:10.5455/ijsm.vegf-a-breast-cancer



Turabian Style

, Daniel Sampepajung Sampepajung, Haryasena, and Muhammad Faruk. 2021. Correlation between vascular endothelial growth factor-a serum with clinical stage, histopathologic grading and estrogen receptor status breast cancer patient in Makassar. International Journal of Surgery and Medicine, 7 (1), 44-48. doi:10.5455/ijsm.vegf-a-breast-cancer



Chicago Style

, Daniel Sampepajung Sampepajung, Haryasena, and Muhammad Faruk. "Correlation between vascular endothelial growth factor-a serum with clinical stage, histopathologic grading and estrogen receptor status breast cancer patient in Makassar." International Journal of Surgery and Medicine 7 (2021), 44-48. doi:10.5455/ijsm.vegf-a-breast-cancer



MLA (The Modern Language Association) Style

, Daniel Sampepajung Sampepajung, Haryasena, and Muhammad Faruk. "Correlation between vascular endothelial growth factor-a serum with clinical stage, histopathologic grading and estrogen receptor status breast cancer patient in Makassar." International Journal of Surgery and Medicine 7.1 (2021), 44-48. Print. doi:10.5455/ijsm.vegf-a-breast-cancer



APA (American Psychological Association) Style

, Sampepajung, . D. S., Haryasena, . & Faruk, . M. (2021) Correlation between vascular endothelial growth factor-a serum with clinical stage, histopathologic grading and estrogen receptor status breast cancer patient in Makassar. International Journal of Surgery and Medicine, 7 (1), 44-48. doi:10.5455/ijsm.vegf-a-breast-cancer