E-ISSN 2367-699X | ISSN 2367-7414
 

Original Research 


A PROSPECTIVE RANDOMIZED COMPARATIVE EVALUATION OF FLUPIRTINE AND DICLOFENAC SODIUM IN POST INGUINAL HERNIA SURGERY PAIN

Jai Karan, R K Karwasra, Rajesh Godara, A R Bansal, Rathindra Tripura.

Cited by (2)

Abstract
Introduction: Effective postoperative pain control is an essential component of care of surgical patients. Nonsteroidal anti-inflammatory drugs are mainstay to treat pain and inflammation. Flupirtine is a novel, non-opiate, non-NSAID, centrally acting analgesic without side effects associated with NSAIDs.
Aim and Objectives: Prospective, randomized, double blind comparative study to evaluate and compare analgesic efficacy of flupirtine with diclofenac sodium in inguinal hernia surgery.
Methods: The study was conducted in tertiary care teaching hospital on 50 patients aged 15-65 yrs of either sex who underwent inguinal hernia surgery between March 2014 and January 2016. Patients with liver and renal failure, hypersensitivity to flupirtine or diclofenac, pregnant/lactating women, bronchospastic disease, inability to understand pain score, prior history of peptic ulcer were excluded from study. The patients were randomly allocated into two groups consisting of 25 patients each: group-A (tab flupirtine 100mg),group-B (tab diclofenac sodium 50mg). Pain was evaluated in detail using simple and sensitive visual analog scale.
Results: The mean age of the participants was 37.5712.02 yrs in group A and 37.8213.43 yrs in group B(p>0.05 ) with male-to-female ratio 3:1. The mean weight of the participants was 66.7212.90 vs 6413.10 kg (p>0.05). The mean VAS values observed were 1.361.77 at baseline, 1.242.18 at 6 hours, 0.601.65 at 12 hours, 0.401.19 at 18 hours, 0.160.62 at 24 hours, 0.080.4 at 30 hours & 36 hours, at 42 and 48 hours were 0 for group A. For group B values calculated were 2.202.58 at baseline, 1.401.55 at 6 hours, 1.281.72 at 12 hours, 0.761.56 at 18 hours, 0.280.61 at 24 hours and at 30, 36, 42 and 48 hours were 0. The intergroup comparison between group A and group B by independent t-test at various intervals revealed no statistically significant difference between two groups in mean VAS (p>.05) that means both the drugs are equally efficacious in relieving post-operative pain. Only 1 patient (4%) in group A experienced nausea. A total of 4 patients in group B had side effects, all 4 patients (16%) had heart burn, 2 out these 4 also complains of pain abdomen and 1 patient (4%) had vomiting.
Conclusion: Flupirtine could be a better alternative to opioids and NSAIDs in postoperative pain relief

Key words: Flupirtine, diclofenac sodium, inguinal hernia, analgesia


 
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REFERENCES
1. Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg 2003;97:534-40. [DOI via Crossref]    [Pubmed]   
2. Raffa RB, Pergolizzi JV Jr. The evolving understanding of the analgesic mechanism of action of flupirtine. Clin Pharm Ther J 2012;37:4–6. [DOI via Crossref]    [Pubmed]   
3. Marczyk LR. Comparative evaluation of flupirtine maleate versus diclofenac potassium in musculoskeletal disorders. Arq Bras Med 1992;66:269-75.
4. Yadav G, Choupoo S, Das SK, Das SK, Behera SS, Khuba S, et al. Evaluating the role of flupirtine for postcraniotomy pain and compare it with diclofenac sodium : A prospective, randomized, double-blind, placebo-controlled study. J Neurosurg Anesthesiol 2014;26:32-6. [DOI via Crossref]    [Pubmed]   
5. Attri JP, Sandhu GK, Khichy S, Singh H, Singh K, Sharan R. Comparative evaluation of oral flupirtine and oral diclofenac sodium for analgesia and adverse effects in elective abdominal surgeries. Anesth Essays Res 2015;9:72-8. [DOI via Crossref]   
6. Mastronardi P, D'Onofrio M, Scanni E, Pinto M, Frontespezi S, Ceccarelli MG. Analgesic activity of flupirtine maleate : a controlled double-blind study with diclofenac sodium in orthopaedics. J Int Med Res 1988;16:338-48. [Pubmed]   
7. Mueller SG. Flupirtine in acute and chronic pain associated with muscle tenseness: results of a postmarket surveillance study. Fortschr Med Orig 2003;121:11-8.
8. Ringe JD, Miethe D, Pittrow D, Wegscheider K. Analgesic efficacy of flupirtine in primary care of patients with osteoporosis related pain: a multivariate analysis. Arzneimittelforschung 2003;53:496-502. [Pubmed]   
9. Naser SM, Sarkar N, Biswas A. Efficacy and safety of flupirtine maleate and tramadol hydrochloride in postoperative pain management-a prospective randomized double blinded study. J Indian Med Assoc 2012;110:158-60. [Pubmed]   
10. Reithmuller WH. Flupirtine in the treatment of postoperative pain. Postgrad Med J 1987;63:61-6.
11. Hodsman NB. The morphine sparing effects of diclofenac sodium following abdominal surgery. Anaesthesia 1987;9:1005-8. [DOI via Crossref]   
12. Scheef W. Analgesic efficacy and safety of oral flupirtine in the treatment of cancer pain. Postgrad Med J 1987;63:67-70. [Pubmed]   
13. Million R, Finlay BR, Whittington JR. Clinical trial of flupirtine maleate in patients with migraine. Curr Med Res Opin 1984;9:204-12. [DOI via Crossref]    [Pubmed]   
14. Luben V, Muller H, Lobisch M, Worz R. Treatment of tumor pain with flupirtine: results of a double-blind study versus tramadol. Fortschr Med 1994;112:282-6. [Pubmed]   
15. Kelly AM. Does the clinically significant difference in VAS pain score differ with age, gender or cause of pain? Acad Emerg Med 1998;5:1086-90. [DOI via Crossref]    [Pubmed]   
16. Todd KH. Clinical versus statistical significance in the assessment of pain relief. Ann Emerg Med 1996;27:439-41. [DOI via Crossref]   
17. Dhar S, Bitting RL, Rylova SN. Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3 and CLN2 deficient neurons. Ann Neurol 2002;51:448-66. [DOI via Crossref]    [Pubmed]   
18. Luben V, Muller H, Lobisch M, Worz R. Treatment of tumor pain with flupirtine: results of a double blind study versus tramadol. Fortschr Med 1994;112:282-6. [Pubmed]   
19. Million R, Finlay BR, Whittington JR. Clinical trial of flupirtine maleate in patients with migraine. Curr Med Res Opin 1984;9:204-12. [DOI via Crossref]    [Pubmed]   
20. Fredman B, Olsfanger D, Jedeikin R. A comparative study of ketorolac and diclofenac on post-laparocopic cholecystectomy pain. Eur J Anesthesiol 1995;12:501-4. [Pubmed]   

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How to Cite this Article
Pubmed Style

Jai Karan, R K Karwasra, Rajesh Godara, A R Bansal, Rathindra Tripura. A PROSPECTIVE RANDOMIZED COMPARATIVE EVALUATION OF FLUPIRTINE AND DICLOFENAC SODIUM IN POST INGUINAL HERNIA SURGERY PAIN. Int J Surg Med. 2016; 2(3): 107-110. doi:10.5455/ijsm.inguinalhernia


Web Style

Jai Karan, R K Karwasra, Rajesh Godara, A R Bansal, Rathindra Tripura. A PROSPECTIVE RANDOMIZED COMPARATIVE EVALUATION OF FLUPIRTINE AND DICLOFENAC SODIUM IN POST INGUINAL HERNIA SURGERY PAIN. http://www.ejos.org/?mno=223455 [Access: November 03, 2020]. doi:10.5455/ijsm.inguinalhernia


AMA (American Medical Association) Style

Jai Karan, R K Karwasra, Rajesh Godara, A R Bansal, Rathindra Tripura. A PROSPECTIVE RANDOMIZED COMPARATIVE EVALUATION OF FLUPIRTINE AND DICLOFENAC SODIUM IN POST INGUINAL HERNIA SURGERY PAIN. Int J Surg Med. 2016; 2(3): 107-110. doi:10.5455/ijsm.inguinalhernia



Vancouver/ICMJE Style

Jai Karan, R K Karwasra, Rajesh Godara, A R Bansal, Rathindra Tripura. A PROSPECTIVE RANDOMIZED COMPARATIVE EVALUATION OF FLUPIRTINE AND DICLOFENAC SODIUM IN POST INGUINAL HERNIA SURGERY PAIN. Int J Surg Med. (2016), [cited November 03, 2020]; 2(3): 107-110. doi:10.5455/ijsm.inguinalhernia



Harvard Style

Jai Karan, R K Karwasra, Rajesh Godara, A R Bansal, Rathindra Tripura (2016) A PROSPECTIVE RANDOMIZED COMPARATIVE EVALUATION OF FLUPIRTINE AND DICLOFENAC SODIUM IN POST INGUINAL HERNIA SURGERY PAIN. Int J Surg Med, 2 (3), 107-110. doi:10.5455/ijsm.inguinalhernia



Turabian Style

Jai Karan, R K Karwasra, Rajesh Godara, A R Bansal, Rathindra Tripura. 2016. A PROSPECTIVE RANDOMIZED COMPARATIVE EVALUATION OF FLUPIRTINE AND DICLOFENAC SODIUM IN POST INGUINAL HERNIA SURGERY PAIN. International Journal of Surgery and Medicine, 2 (3), 107-110. doi:10.5455/ijsm.inguinalhernia



Chicago Style

Jai Karan, R K Karwasra, Rajesh Godara, A R Bansal, Rathindra Tripura. "A PROSPECTIVE RANDOMIZED COMPARATIVE EVALUATION OF FLUPIRTINE AND DICLOFENAC SODIUM IN POST INGUINAL HERNIA SURGERY PAIN." International Journal of Surgery and Medicine 2 (2016), 107-110. doi:10.5455/ijsm.inguinalhernia



MLA (The Modern Language Association) Style

Jai Karan, R K Karwasra, Rajesh Godara, A R Bansal, Rathindra Tripura. "A PROSPECTIVE RANDOMIZED COMPARATIVE EVALUATION OF FLUPIRTINE AND DICLOFENAC SODIUM IN POST INGUINAL HERNIA SURGERY PAIN." International Journal of Surgery and Medicine 2.3 (2016), 107-110. Print. doi:10.5455/ijsm.inguinalhernia



APA (American Psychological Association) Style

Jai Karan, R K Karwasra, Rajesh Godara, A R Bansal, Rathindra Tripura (2016) A PROSPECTIVE RANDOMIZED COMPARATIVE EVALUATION OF FLUPIRTINE AND DICLOFENAC SODIUM IN POST INGUINAL HERNIA SURGERY PAIN. International Journal of Surgery and Medicine, 2 (3), 107-110. doi:10.5455/ijsm.inguinalhernia