E-ISSN 2367-699X | ISSN 2367-7414
 

Case Report 


SMALL CELL NEUROENDOCRINE CARCINOMA OF THE BLADDER: REPORT OF FOUR CASES AND A REVIEW OF THE LITERATURE

Imane Bourhafour, Sanaa Elmajjaoui, Hanane Elkacemi, Tayeb Kebdani, Noureddine Benjaafar, Mila Kayryakova, Ivan Inkov.

Abstract
Purpose: Small cell neuroendocrine bladder carcinoma is a rare entity, account for less than 1% of all bladder tumors. They are of particular histological entity characterized by an aggressive clinical behaviour, high potential for metastatic spread and poor prognosis. The aim of this study was to describe the epidemiological, clinical, therapeutic modalities and the evolution data of small cell neuroendocrine bladder carcinomas.
Patients and methods: During a period of 10 years, four patients with neuroendocrine bladder carcinoma were treated at the National Institute of Oncology in Rabat.
Results: The median age was 66 years. There were three men and a woman. Neuroendocrine carcinoma was pure in one case and associated with transitional cell carcinoma in the other three cases. Two patients were diagnosed with lymph nodes involvement and one patient at a metastatic stage. A cystectomy was performed in one case. Two patients received a concurrent chemoradiation and the fourth patient received chemotherapy alone. A single case of complete remission was observed. Median survival was 18 months (630 months). Only one patient is still alive 30 months after diagnosis.
Conclusion: The management of neuroendocrine carcinoma of the bladder remains debated and vary from institution to author. Despite multimodality regimens, the prognosis of these tumours remains poor.

Key words: Small cell carcinoma, bladder, diagnosis, radiotherapy, chemotherapy, surgery


 
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How to Cite this Article
Pubmed Style

Imane Bourhafour, Sanaa Elmajjaoui, Hanane Elkacemi, Tayeb Kebdani, Noureddine Benjaafar, Mila Kayryakova, Ivan Inkov. SMALL CELL NEUROENDOCRINE CARCINOMA OF THE BLADDER: REPORT OF FOUR CASES AND A REVIEW OF THE LITERATURE. Int J Surg Med. 2018; 4(2): 96-100. doi:10.5455/ijsm.small-cell-neuroendocrine-carcinoma-management


Web Style

Imane Bourhafour, Sanaa Elmajjaoui, Hanane Elkacemi, Tayeb Kebdani, Noureddine Benjaafar, Mila Kayryakova, Ivan Inkov. SMALL CELL NEUROENDOCRINE CARCINOMA OF THE BLADDER: REPORT OF FOUR CASES AND A REVIEW OF THE LITERATURE. http://www.ejos.org/?mno=234988 [Access: November 03, 2020]. doi:10.5455/ijsm.small-cell-neuroendocrine-carcinoma-management


AMA (American Medical Association) Style

Imane Bourhafour, Sanaa Elmajjaoui, Hanane Elkacemi, Tayeb Kebdani, Noureddine Benjaafar, Mila Kayryakova, Ivan Inkov. SMALL CELL NEUROENDOCRINE CARCINOMA OF THE BLADDER: REPORT OF FOUR CASES AND A REVIEW OF THE LITERATURE. Int J Surg Med. 2018; 4(2): 96-100. doi:10.5455/ijsm.small-cell-neuroendocrine-carcinoma-management



Vancouver/ICMJE Style

Imane Bourhafour, Sanaa Elmajjaoui, Hanane Elkacemi, Tayeb Kebdani, Noureddine Benjaafar, Mila Kayryakova, Ivan Inkov. SMALL CELL NEUROENDOCRINE CARCINOMA OF THE BLADDER: REPORT OF FOUR CASES AND A REVIEW OF THE LITERATURE. Int J Surg Med. (2018), [cited November 03, 2020]; 4(2): 96-100. doi:10.5455/ijsm.small-cell-neuroendocrine-carcinoma-management



Harvard Style

Imane Bourhafour, Sanaa Elmajjaoui, Hanane Elkacemi, Tayeb Kebdani, Noureddine Benjaafar, Mila Kayryakova, Ivan Inkov (2018) SMALL CELL NEUROENDOCRINE CARCINOMA OF THE BLADDER: REPORT OF FOUR CASES AND A REVIEW OF THE LITERATURE. Int J Surg Med, 4 (2), 96-100. doi:10.5455/ijsm.small-cell-neuroendocrine-carcinoma-management



Turabian Style

Imane Bourhafour, Sanaa Elmajjaoui, Hanane Elkacemi, Tayeb Kebdani, Noureddine Benjaafar, Mila Kayryakova, Ivan Inkov. 2018. SMALL CELL NEUROENDOCRINE CARCINOMA OF THE BLADDER: REPORT OF FOUR CASES AND A REVIEW OF THE LITERATURE. International Journal of Surgery and Medicine, 4 (2), 96-100. doi:10.5455/ijsm.small-cell-neuroendocrine-carcinoma-management



Chicago Style

Imane Bourhafour, Sanaa Elmajjaoui, Hanane Elkacemi, Tayeb Kebdani, Noureddine Benjaafar, Mila Kayryakova, Ivan Inkov. "SMALL CELL NEUROENDOCRINE CARCINOMA OF THE BLADDER: REPORT OF FOUR CASES AND A REVIEW OF THE LITERATURE." International Journal of Surgery and Medicine 4 (2018), 96-100. doi:10.5455/ijsm.small-cell-neuroendocrine-carcinoma-management



MLA (The Modern Language Association) Style

Imane Bourhafour, Sanaa Elmajjaoui, Hanane Elkacemi, Tayeb Kebdani, Noureddine Benjaafar, Mila Kayryakova, Ivan Inkov. "SMALL CELL NEUROENDOCRINE CARCINOMA OF THE BLADDER: REPORT OF FOUR CASES AND A REVIEW OF THE LITERATURE." International Journal of Surgery and Medicine 4.2 (2018), 96-100. Print. doi:10.5455/ijsm.small-cell-neuroendocrine-carcinoma-management



APA (American Psychological Association) Style

Imane Bourhafour, Sanaa Elmajjaoui, Hanane Elkacemi, Tayeb Kebdani, Noureddine Benjaafar, Mila Kayryakova, Ivan Inkov (2018) SMALL CELL NEUROENDOCRINE CARCINOMA OF THE BLADDER: REPORT OF FOUR CASES AND A REVIEW OF THE LITERATURE. International Journal of Surgery and Medicine, 4 (2), 96-100. doi:10.5455/ijsm.small-cell-neuroendocrine-carcinoma-management