E-ISSN 2367-699X | ISSN 2367-7414
 

Original Article

Online Publishing Date:
26 / 03 / 2023

 


Post neoadjuvant chemotherapy Histopathological evaluation of breast cancer specimens

Mamita Nayak, Kusumbati Besra, Sagarika Samantaray, Prajna Sucharita Nayak.


Abstract
Aims: Breast carcinomas in locally advanced cases are usually treated with neoadjuvant chemotherapy(NACT). Now adays it is also extended to some cases of early and operable breast cancer cases also.The aim of the study is to highlight the histopathological changes observed after neoadjuvant chemotherapy breast cancer specimens and to evaluate the role of histopathological examination in assessing the complete response (pCR), pathological partial response (pPR) and pathological no response(pNR).
Methods: A retrospective one year study carried out in our tertiary care cancer centre from January 2019 to December 2019. Pathological response to NACT were assessed in terms of the residual tumour size, histological grade, lymphovascular space invasion, fibrosis, calcification , histiocytes and the necrosis. Pathological response was calculated by the residual cancer burden(RCB) and the tumour node metastases (ypTNM) staging system was determined by the 8th edition of AJCC(American joint cancer committee) staging guidelines.
Results: A total of 143 breast cancer patients treated with NACT followed by surgery were included. Of the 143 cases of post NACT ,115 cases had residual cancer(80.41% ) and 28 cases(19.5%) showed complete pathological response. Grossly(macroscopically) the tumour was identifiable in 68% of cases. Histologically,most of the residual carcinomas post NACT were invasive ductal carcinoma of no special type. About 70 cases (48.95%) of the post NACT breast cancer patients were of grade 2. Necrosis was noted in 41.2% (59out of 143 cases) .98 cases(68%) showed lymphnode metastasis. pCR was seen in 19.5% of cases, pPR was noted in 74.12% of cases and 6.29% were pNR.
Conclusions: NACT followed by surgery is a treatment modality in management of locally advanced breast cancer. It is now also promising treatment strategy which can be extended for the management of early stage and in operable breast cancers. This study focuses on the easily reproducible histopathological parameters and their inclusion in the histopathology report. Histopathological evaluation can predict the response to chemotherapy and can impact the further course of treatment.

Key words: Breast cancer, Neoadjuvant chemotherapy, pathological evaluation, pathologic complete response


 
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How to Cite this Article
Pubmed Style

Nayak M, Besra K, Samantaray S, Nayak PS. Post neoadjuvant chemotherapy Histopathological evaluation of breast cancer specimens. Int J Surg Med. 2023; 9(1): 20-26. doi:10.5455/ijsm.136-1668325666


Web Style

Nayak M, Besra K, Samantaray S, Nayak PS. Post neoadjuvant chemotherapy Histopathological evaluation of breast cancer specimens. https://www.ejos.org/?mno=129537 [Access: July 18, 2024]. doi:10.5455/ijsm.136-1668325666


AMA (American Medical Association) Style

Nayak M, Besra K, Samantaray S, Nayak PS. Post neoadjuvant chemotherapy Histopathological evaluation of breast cancer specimens. Int J Surg Med. 2023; 9(1): 20-26. doi:10.5455/ijsm.136-1668325666



Vancouver/ICMJE Style

Nayak M, Besra K, Samantaray S, Nayak PS. Post neoadjuvant chemotherapy Histopathological evaluation of breast cancer specimens. Int J Surg Med. (2023), [cited July 18, 2024]; 9(1): 20-26. doi:10.5455/ijsm.136-1668325666



Harvard Style

Nayak, M., Besra, . K., Samantaray, . S. & Nayak, . P. S. (2023) Post neoadjuvant chemotherapy Histopathological evaluation of breast cancer specimens. Int J Surg Med, 9 (1), 20-26. doi:10.5455/ijsm.136-1668325666



Turabian Style

Nayak, Mamita, Kusumbati Besra, Sagarika Samantaray, and Prajna Sucharita Nayak. 2023. Post neoadjuvant chemotherapy Histopathological evaluation of breast cancer specimens. International Journal of Surgery and Medicine, 9 (1), 20-26. doi:10.5455/ijsm.136-1668325666



Chicago Style

Nayak, Mamita, Kusumbati Besra, Sagarika Samantaray, and Prajna Sucharita Nayak. "Post neoadjuvant chemotherapy Histopathological evaluation of breast cancer specimens." International Journal of Surgery and Medicine 9 (2023), 20-26. doi:10.5455/ijsm.136-1668325666



MLA (The Modern Language Association) Style

Nayak, Mamita, Kusumbati Besra, Sagarika Samantaray, and Prajna Sucharita Nayak. "Post neoadjuvant chemotherapy Histopathological evaluation of breast cancer specimens." International Journal of Surgery and Medicine 9.1 (2023), 20-26. Print. doi:10.5455/ijsm.136-1668325666



APA (American Psychological Association) Style

Nayak, M., Besra, . K., Samantaray, . S. & Nayak, . P. S. (2023) Post neoadjuvant chemotherapy Histopathological evaluation of breast cancer specimens. International Journal of Surgery and Medicine, 9 (1), 20-26. doi:10.5455/ijsm.136-1668325666