E-ISSN 2367-699X | ISSN 2367-7414
 
2022, Vol: 8, Issue: 6
8/6Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Copyright Transfer Form

Original Article 


THE COMPARISON OF EVENING PRIMROSE OIL, FRUCTUS AGNI CASTI AND REASSURANCE IN THE TREATMENT OF MASTALGIA

Murat Özgür Kılıç, Meral Şen, Duygu İçen.

Cited by (1)

Abstract
Background: Although many therapeutic options have been used in the treatment of mastalgia, none of those has a curative effect.
Aim: In this study, we aimed to investigate the effects of evening primrose oil, Fructus Agni Casti and reassurance on mastalgia, in comparison to placebo.
Methods: This is a prospective clinical study on the effectiveness of evening primrose oil, Fructus Agni Casti and reassurance in the treatment of mastalgia. One hundred twenty-eight female patients with mastalgia were placed randomly into four groups: (1) evening primrose oil, (2) Fructus Agni Casti, (3) reassurance, and (4) placebo, for the treatment of 3 months. The severity and type of mastalgia were evaluated according to the Breast Pain Questionnaire. Response to treatment was assessed by the Cardiff Breast Pain scoring system.
RESULTS: Fructus Agni Casti group had a more effective therapeutic response when compared with other groups. Reassurance and evening primrose oil groups had similar effects on reducing breast pain. The worst response to treatment was obtained in the placebo group. During follow-up, no serious adverse effect was observed.
CONCLUSION: Fructus Agni Casti can be used in mastalgia patients with a high success rate and less adverse effect profile. Reassurance may be an important part of mastalgia management, due to the psychological basis of this entity.

Key words: Evening primrose oil, fructus agni casti, mastalgia treatment, premenstrual syndrome


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Murat Özgür Kılıç
Articles by Meral Åžen
Articles by Duygu İçen
on Google
on Google Scholar


REFERENCES
1. Johnson KM, Bradley KA, Bush K, Gardella C, Dobie DJ, Laya MB. The frequency of mastalgia among women veterans. Association with psychiatric conditions and unexplained pain syndromes. J Gen Intern Med 2006; 21:70-75. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
2. Carmichael AR. Can Vitex Agnus Castus be Used for the Treatment of Mastalgia? What is the Current Evidence? Evid Based Complement Alternat Med 2008; 5:247-250. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
3. Olawaiye A, Withiam-Leitch M, Danakas G, Kahn KJ. Mastalgia: a review of management. J Reprod Med 2005; 50:933-939. [Pubmed]   
4. Faiz O, Fentiman IS. Management of breast pain. Int J Clin Pract 2000; 54:228-232. [Pubmed]   
5. Smith RL, Pruthi S, Fitzpatrick LA. Evaluation and management of breast pain. Mayo Clin Proc 2004; 79:353-372. [DOI via Crossref]    [Pubmed]   
6. Pruthi S, Wahner-Roedler DL, Torkelson CJ, Cha SS, Thicke LS, Hazelton JH, et al. Vitamin E and evening primrose oil for management of cyclical mastalgia: a randomized pilot study. Altern Med Rev 2010; 15:59-67. [Pubmed]   
7. Gregory PL, Biswas AC, Batt ME. Musculoskeletal problems of the chest wall in athletes. Sports Med 2002; 32:235-250. [DOI via Crossref]    [Pubmed]   
8. Srivastava A, Mansel RE, Arvind N, Prasad K, Dhar A, Chabra A. Evidence-based management of Mastalgia: a meta-analysis of randomized trials. Breast 2007; 16:503-512. [DOI via Crossref]    [Pubmed]   
9. Salzman B, Fleegle S, Tully AS. Common breast problems. Am Fam Physician 2012; 86:343-349. [Pubmed]   
10. Gateley CA, Miers M, Mansel RE, Hughes LE. Drug treatments for mastalgia: 17 years experience in the Cardiff Mastalgia Clinic. J R Soc Med 1992; 85:12-15. [Pubmed]    [PMC Free Fulltext]   
11. Ader DN, Browne MW. Prevalence and impact of cyclic mastalgia in a United States clinic-based sample. Am J Obstet Gynecol 1997; 177:126-132. [DOI via Crossref]   
12. Aiello EJ, Buist DS, White E, Seger D, Taplin SH. Rate of breast cancer diagnoses among postmenopausal women with self-reported breast symptoms. J Am Board Fam Pract 2004; 17:408-415. [DOI via Crossref]    [Pubmed]   
13. Khan SA, Aprakian AV. Mastalgia and breast cancer. A protective association? Cancer Detect Prev 2002; 26:192-196. [DOI via Crossref]   
14. Millet AV, Dirbas FM. Clinical management of breast pain: a review. Obstet Gynecol Surv 2002; 57:451-461. [DOI via Crossref]   
15. Barros AC, Mottola J, Ruiz CA, Borges MN, Pinotti JA. Reassurance in the Treatment of Mastalgia. Breast J 1999; 5:162-165. [DOI via Crossref]    [Pubmed]   
16. Rezapour-Firouzi S, Arefhosseini SR, Mehdi F, Mehrangiz EM, Baradaran B, Sadeghihokmabad E, et al. Immunomodulatory and therapeutic effects of Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. Complement Ther Med 2013; 21:473-480. [DOI via Crossref]    [Pubmed]   
17. Blommers J, de Lange-De Klerk ES, Kuik DJ, Bezemer PD, Meijer S. Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial. Am J Obstet Gynecol 2002; 187:1389-1394. [DOI via Crossref]    [Pubmed]   
18. Wuttke W, Jarry H, Christoffel V, Spengler B, Seidlová-Wuttke D. Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications. Phytomedicine 2003; 10:348-357. [DOI via Crossref]    [Pubmed]   
19. Webster DE, He Y, Chen SN, Pauli GF, Farnsworth NR, Wang ZJ. Opioidergic mechanisms underlying the actions of Vitex agnus-castus L. Biochem Pharmacol 2011; 81:170-177. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
20. He Z, Chen R, Zhou Y, Geng L, Zhang Z, Chen S, et al. Treatment for a premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China. Maturitas 2009; 63:99-103. [DOI via Crossref]    [Pubmed]   
21. Schellenberg R, Zimmermann C, Drewe J, Hoexter G, Zahner C. Dose-dependent efficacy of the Vitex agnus castus extract Ze 440 in patients suffering from premenstrual syndrome. Phytomedicine 2012; 19:1325-1331. [DOI via Crossref]    [Pubmed]   
22. Berger D, Schaffner W, Schrader E, Meier B, Brattstrom A. Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS). Arch Gynecol Obstet 2000; 264:150-153. [DOI via Crossref]    [Pubmed]   
23. Loch EG, Selle H, Boblitz N. Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus. J Womens Health Gend Based Med 2000; 9:315-320. [DOI via Crossref]    [Pubmed]   
24. Kilicdag EB, Tarim E, Bagis T, Erkanli S, Aslan E, Ozsahin K, et al. Fructus agni casti and bromocriptine for treatment of hyperprolactinemia and mastalgia. Int J Gynaecol Obstet 2004; 85:292-293. [DOI via Crossref]    [Pubmed]   
25. Wuttke W. The use of chasteberry (Vitex agnus castus) extract in gynecology. Gynäkol Endokrinol 2008; 6:82-86. [DOI via Crossref]   
26. Daniele C, Thompson Coon J, Pittler MH, Ernst E. Vitex agnus castus: a systematic review of adverse events. Drug Saf 2005; 28:319-332. [DOI via Crossref]    [Pubmed]   
27. Dennehy CE. The use of herbs and dietary supplements in gynecology: an evidence-based review. J Midwifery Womens Health 2006; 51:402-409. [DOI via Crossref]    [Pubmed]   
28. Goyal A, Mansel RE; Efamast Study Group. A randomized multicenter study of gamolenic acid (Efamast) with and without antioxidant vitamins and minerals in the management of mastalgia. Breast J 2005; 11:41-47. [DOI via Crossref]    [Pubmed]   
29. Tejwani PL, Srivastava A, Nerkar H, Dhar A, Hari S, Thulkar S, et al. Centchroman regresses mastalgia: a randomized comparison with danazol. Indian J Surg 2011; 73:199-205. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
30. Bayles B, Usatine R. Evening primrose oil. Am Fam Physician 2009; 80:1405-1408. [Pubmed]   
31. Genc V, Genc A, Ustuner E, Dusunceli EB, Oztuna D, Bayar S, et al. Is there an association between mastalgia and fibromyalgia? Comparing prevalence and symptom severity. Breast 2011; 20:314-318. [DOI via Crossref]    [Pubmed]   
32. Colegrave S, Holcombe C, Salmon P. Psychological characteristics of women presenting with breast pain. J Psychosom Res 2001; 50:303-307. [DOI via Crossref]   
33. Ader DN, South-Paul J, Adera T, Deuster PA. Cyclical mastalgia: prevalence and associated health and behavioral factors. J Psychosom Obstet Gynaecol 2001; 22:71-76. [DOI via Crossref]    [Pubmed]   

This Article Cited By the following articles

A Systematic Review and Meta-Analysis of the Efficacy of Evening Primrose Oil for Mastalgia Treatment
IJERPH 2021; 18(12): 6295.

1
 
How to Cite this Article
Pubmed Style

Murat Ozgur Kılıc, Meral Şen, Duygu İcen. THE COMPARISON OF EVENING PRIMROSE OIL, FRUCTUS AGNI CASTI AND REASSURANCE IN THE TREATMENT OF MASTALGIA. Int J Surg Med. 2016; 2(2): 83-88. doi:10.5455/ijsm.mastalgia

Web Style

Murat Ozgur Kılıc, Meral Şen, Duygu İcen. THE COMPARISON OF EVENING PRIMROSE OIL, FRUCTUS AGNI CASTI AND REASSURANCE IN THE TREATMENT OF MASTALGIA. https://www.ejos.org/?mno=215347 [Access: January 11, 2023]. doi:10.5455/ijsm.mastalgia

AMA (American Medical Association) Style

Murat Ozgur Kılıc, Meral Şen, Duygu İcen. THE COMPARISON OF EVENING PRIMROSE OIL, FRUCTUS AGNI CASTI AND REASSURANCE IN THE TREATMENT OF MASTALGIA. Int J Surg Med. 2016; 2(2): 83-88. doi:10.5455/ijsm.mastalgia


Vancouver/ICMJE Style

Murat Ozgur Kılıc, Meral Şen, Duygu İcen. THE COMPARISON OF EVENING PRIMROSE OIL, FRUCTUS AGNI CASTI AND REASSURANCE IN THE TREATMENT OF MASTALGIA. Int J Surg Med. (2016), [cited January 11, 2023]; 2(2): 83-88. doi:10.5455/ijsm.mastalgia


Harvard Style

Murat Ozgur Kılıc, Meral Şen, Duygu İcen (2016) THE COMPARISON OF EVENING PRIMROSE OIL, FRUCTUS AGNI CASTI AND REASSURANCE IN THE TREATMENT OF MASTALGIA. Int J Surg Med, 2 (2), 83-88. doi:10.5455/ijsm.mastalgia


Turabian Style

Murat Ozgur Kılıc, Meral Şen, Duygu İcen. 2016. THE COMPARISON OF EVENING PRIMROSE OIL, FRUCTUS AGNI CASTI AND REASSURANCE IN THE TREATMENT OF MASTALGIA. International Journal of Surgery and Medicine, 2 (2), 83-88. doi:10.5455/ijsm.mastalgia


Chicago Style

Murat Ozgur Kılıc, Meral Şen, Duygu İcen. "THE COMPARISON OF EVENING PRIMROSE OIL, FRUCTUS AGNI CASTI AND REASSURANCE IN THE TREATMENT OF MASTALGIA." International Journal of Surgery and Medicine 2 (2016), 83-88. doi:10.5455/ijsm.mastalgia


MLA (The Modern Language Association) Style

Murat Ozgur Kılıc, Meral Şen, Duygu İcen. "THE COMPARISON OF EVENING PRIMROSE OIL, FRUCTUS AGNI CASTI AND REASSURANCE IN THE TREATMENT OF MASTALGIA." International Journal of Surgery and Medicine 2.2 (2016), 83-88. Print. doi:10.5455/ijsm.mastalgia


APA (American Psychological Association) Style

Murat Ozgur Kılıc, Meral Şen, Duygu İcen (2016) THE COMPARISON OF EVENING PRIMROSE OIL, FRUCTUS AGNI CASTI AND REASSURANCE IN THE TREATMENT OF MASTALGIA. International Journal of Surgery and Medicine, 2 (2), 83-88. doi:10.5455/ijsm.mastalgia


Author LoginReviewer LoginAbout PublisherEditorial PoliciesPeer Review PolicyEditorial & Peer Review ProcessAuthor's Rights and ObligationsPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information
Copyright © 2023 International Journal of Surgery and Medicine All Rights Reserved. Subject to change without notice from or liability to International Journal of Surgery and Medicine.
For best results, please use Internet Explorer or Google Chrome

Contact Information


 

Any correspondence, queries or additional requests for information on the manuscript submission process should be sent to the International Journal of Surgery and Medicine editorial office as follows:

Bulgarian Association of Young Surgeons (BAYS)

inkov@journalmedica.com

Financial department is managed by International Sci Ink Press. 

It is a company registered in Bulgaria with registered no. 205414288 and registered address at 57 Antim I str., Vazrazhdane, Sofia, 1303, Bulgaria.

Tel: +359883427500