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Original Article
Online Published: 23 Aug 2019
 


Use of ursodeoxycholic acid as a prophylaxis from gall stones after bariatric surgery: A case control study

Abdulgadir Talal Atteiah, Wisam Jamal, Ali Mohammed Nasr, Abdulaziz Abdullah Basurrah, Saud Abdullah Alazdi, Abdulmalik Altaf.


Abstract
Introduction: Several studies have shown a strong relation between rapid loss of weight after bariatric surgery and developing gallstones. Some surgeons prescribe ursodeoxycholic acid for prevention of gallstones formation. But major guidelines make no definite statement about postoperative ursodeoxycholic acid as prophylaxis. The aim of this study was to evaluate postoperative use of ursodeoxycholic acid and the gallstones disease development in patients who underwent bariatric surgery.
Methods: This case-control study was conducted at University Hospital. All patients who underwent bariatric surgery between 2012 to 2017 were included, while patients who had history of cholecystectomy and those with symptomatic gallstones before the surgery were excluded. Data were collected from medical records including age, gender, type of surgery, BMI, ursodeoxycholic acid use, gallstone symptoms, and ultrasound findings before and after the surgery.
Results: Eighty-two patients were included in this study, 56 (68.3%) were females. Their mean age was 36.9±10.8 and mean BMI was 46.7±8.9. Out of 82 operations, 49 (59.8%) had laparoscopic gastric reduction, while 33 (40.2%) had mini gastric bypass. Ten patients (12.19%) developed symptomatic gall stones disease; 3(3.7%) at 3 months, 4 (4.9%) at 6 months, another three cases at 9, 12, and 18 months. ursodeoxycholic acid use for 6 months showed a statistically significant association with the absence of symptomatic gallstones. But its use for only three months did not show this significant relationship.
Conclusion: Ursodeoxycholic acid use for 6 months after bariatric surgery was associated with lower incidence of symptomatic gall stones disease.

Key words: bariatric surgery, sleeve gastrectomy, gastric bypass, gallstones, ursodeoxycholic acid


 
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How to Cite this Article
Pubmed Style

Atteiah AT, Jamal W, Nasr AM, Basurrah AA, Alazdi SA, Altaf A. Use of ursodeoxycholic acid as a prophylaxis from gall stones after bariatric surgery: A case control study. Int J Surg Med. 2019; 5(3): 109-113. doi:10.5455/ijsm.ursodeoxy-acid-bariatric-surgery

Web Style

Atteiah AT, Jamal W, Nasr AM, Basurrah AA, Alazdi SA, Altaf A. Use of ursodeoxycholic acid as a prophylaxis from gall stones after bariatric surgery: A case control study. https://www.ejos.org/?mno=33212 [Access: September 12, 2024]. doi:10.5455/ijsm.ursodeoxy-acid-bariatric-surgery

AMA (American Medical Association) Style

Atteiah AT, Jamal W, Nasr AM, Basurrah AA, Alazdi SA, Altaf A. Use of ursodeoxycholic acid as a prophylaxis from gall stones after bariatric surgery: A case control study. Int J Surg Med. 2019; 5(3): 109-113. doi:10.5455/ijsm.ursodeoxy-acid-bariatric-surgery


Vancouver/ICMJE Style

Atteiah AT, Jamal W, Nasr AM, Basurrah AA, Alazdi SA, Altaf A. Use of ursodeoxycholic acid as a prophylaxis from gall stones after bariatric surgery: A case control study. Int J Surg Med. (2019), [cited September 12, 2024]; 5(3): 109-113. doi:10.5455/ijsm.ursodeoxy-acid-bariatric-surgery


Harvard Style

Atteiah, A. T., Jamal, . W., Nasr, . A. M., Basurrah, . A. A., Alazdi, . S. A. & Altaf, . A. (2019) Use of ursodeoxycholic acid as a prophylaxis from gall stones after bariatric surgery: A case control study. Int J Surg Med, 5 (3), 109-113. doi:10.5455/ijsm.ursodeoxy-acid-bariatric-surgery


Turabian Style

Atteiah, Abdulgadir Talal, Wisam Jamal, Ali Mohammed Nasr, Abdulaziz Abdullah Basurrah, Saud Abdullah Alazdi, and Abdulmalik Altaf. 2019. Use of ursodeoxycholic acid as a prophylaxis from gall stones after bariatric surgery: A case control study. International Journal of Surgery and Medicine, 5 (3), 109-113. doi:10.5455/ijsm.ursodeoxy-acid-bariatric-surgery


Chicago Style

Atteiah, Abdulgadir Talal, Wisam Jamal, Ali Mohammed Nasr, Abdulaziz Abdullah Basurrah, Saud Abdullah Alazdi, and Abdulmalik Altaf. "Use of ursodeoxycholic acid as a prophylaxis from gall stones after bariatric surgery: A case control study." International Journal of Surgery and Medicine 5 (2019), 109-113. doi:10.5455/ijsm.ursodeoxy-acid-bariatric-surgery


MLA (The Modern Language Association) Style

Atteiah, Abdulgadir Talal, Wisam Jamal, Ali Mohammed Nasr, Abdulaziz Abdullah Basurrah, Saud Abdullah Alazdi, and Abdulmalik Altaf. "Use of ursodeoxycholic acid as a prophylaxis from gall stones after bariatric surgery: A case control study." International Journal of Surgery and Medicine 5.3 (2019), 109-113. Print. doi:10.5455/ijsm.ursodeoxy-acid-bariatric-surgery


APA (American Psychological Association) Style

Atteiah, A. T., Jamal, . W., Nasr, . A. M., Basurrah, . A. A., Alazdi, . S. A. & Altaf, . A. (2019) Use of ursodeoxycholic acid as a prophylaxis from gall stones after bariatric surgery: A case control study. International Journal of Surgery and Medicine, 5 (3), 109-113. doi:10.5455/ijsm.ursodeoxy-acid-bariatric-surgery


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