E-ISSN 2367-699X | ISSN 2367-7414
 

Case Report
Online Published: 31 Jan 2016
 


CEREBRAL PHAEOHYPHOMYCOSIS CAUSED BY FONSECAEA MONOPHORA: FIRST REPORT FROM INDIA

Prithvi Varghese, Muhammed Jasim Abdul Jalal, Suhail Ahmad, Ziauddin Khan, Molly Johny, Pushpa Mahadevan, Leena Joseph, Rachel Chandy, Susy Paul.


Cited By: 3

Abstract
We report a case of cerebral phaeohyphomycosis caused by a dematiaceous fungus, Fonsecaea monophora, in a patient with type 2 diabetes mellitus and decompensated chronic liver disease. CT brain revealed a 2x2cm hypodense cystic lesion in the right lentiform nucleus region with significant perilesional edema. Stereotactic burr hole aspiration of the lesion with biopsy of the abscess wall was done, and the aspirated pus from the lesion showed branched, septate hyphae with light brown pigmentation. The culture of the pus grew a dematiaceous fungus, identified by morphological and molecular studies as Fonsecaea monophora. The isolate was susceptible to voriconazole (MIC, 0.004 µg/ml) but showed reduced susceptibility to amphotericin B (MIC, four µg/ml). The patient’s caregivers were not willing for a decompressive procedure and hence was treated medically with combined Amphotericin B and voriconazole antifungal therapy. Ultimately, the patient expired due to raised intracranial tension and resultant brain-stem dysfunction. It is the first case of cerebral phaeohyphomycosis caused by Fonsecaea monophora reported from India.

Key words: Brain Abscess; Cerebral phaeohyphomycosis; Dematiaceous fungus; Fonsecaea monophora


 
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This Article Cited By the following articles

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How to Cite this Article
Pubmed Style

Varghese P, Jalal MJA, Ahmad S, Khan Z, Johny M, Mahadevan P, Joseph L, Chandy R, Paul S. CEREBRAL PHAEOHYPHOMYCOSIS CAUSED BY FONSECAEA MONOPHORA: FIRST REPORT FROM INDIA. Int J Surg Med. 2016; 2(1): 44-49. doi:10.5455/ijsm.neurosurgery01


Web Style

Varghese P, Jalal MJA, Ahmad S, Khan Z, Johny M, Mahadevan P, Joseph L, Chandy R, Paul S. CEREBRAL PHAEOHYPHOMYCOSIS CAUSED BY FONSECAEA MONOPHORA: FIRST REPORT FROM INDIA. https://www.ejos.org/?mno=206835 [Access: June 22, 2026]. doi:10.5455/ijsm.neurosurgery01


AMA (American Medical Association) Style

Varghese P, Jalal MJA, Ahmad S, Khan Z, Johny M, Mahadevan P, Joseph L, Chandy R, Paul S. CEREBRAL PHAEOHYPHOMYCOSIS CAUSED BY FONSECAEA MONOPHORA: FIRST REPORT FROM INDIA. Int J Surg Med. 2016; 2(1): 44-49. doi:10.5455/ijsm.neurosurgery01



Vancouver/ICMJE Style

Varghese P, Jalal MJA, Ahmad S, Khan Z, Johny M, Mahadevan P, Joseph L, Chandy R, Paul S. CEREBRAL PHAEOHYPHOMYCOSIS CAUSED BY FONSECAEA MONOPHORA: FIRST REPORT FROM INDIA. Int J Surg Med. (2016), [cited June 22, 2026]; 2(1): 44-49. doi:10.5455/ijsm.neurosurgery01



Harvard Style

Varghese, P., Jalal, . M. J. A., Ahmad, . S., Khan, . Z., Johny, . M., Mahadevan, . P., Joseph, . L., Chandy, . R. & Paul, . S. (2016) CEREBRAL PHAEOHYPHOMYCOSIS CAUSED BY FONSECAEA MONOPHORA: FIRST REPORT FROM INDIA. Int J Surg Med, 2 (1), 44-49. doi:10.5455/ijsm.neurosurgery01



Turabian Style

Varghese, Prithvi, Muhammed Jasim Abdul Jalal, Suhail Ahmad, Ziauddin Khan, Molly Johny, Pushpa Mahadevan, Leena Joseph, Rachel Chandy, and Susy Paul. 2016. CEREBRAL PHAEOHYPHOMYCOSIS CAUSED BY FONSECAEA MONOPHORA: FIRST REPORT FROM INDIA. International Journal of Surgery and Medicine, 2 (1), 44-49. doi:10.5455/ijsm.neurosurgery01



Chicago Style

Varghese, Prithvi, Muhammed Jasim Abdul Jalal, Suhail Ahmad, Ziauddin Khan, Molly Johny, Pushpa Mahadevan, Leena Joseph, Rachel Chandy, and Susy Paul. "CEREBRAL PHAEOHYPHOMYCOSIS CAUSED BY FONSECAEA MONOPHORA: FIRST REPORT FROM INDIA." International Journal of Surgery and Medicine 2 (2016), 44-49. doi:10.5455/ijsm.neurosurgery01



MLA (The Modern Language Association) Style

Varghese, Prithvi, Muhammed Jasim Abdul Jalal, Suhail Ahmad, Ziauddin Khan, Molly Johny, Pushpa Mahadevan, Leena Joseph, Rachel Chandy, and Susy Paul. "CEREBRAL PHAEOHYPHOMYCOSIS CAUSED BY FONSECAEA MONOPHORA: FIRST REPORT FROM INDIA." International Journal of Surgery and Medicine 2.1 (2016), 44-49. Print. doi:10.5455/ijsm.neurosurgery01



APA (American Psychological Association) Style

Varghese, P., Jalal, . M. J. A., Ahmad, . S., Khan, . Z., Johny, . M., Mahadevan, . P., Joseph, . L., Chandy, . R. & Paul, . S. (2016) CEREBRAL PHAEOHYPHOMYCOSIS CAUSED BY FONSECAEA MONOPHORA: FIRST REPORT FROM INDIA. International Journal of Surgery and Medicine, 2 (1), 44-49. doi:10.5455/ijsm.neurosurgery01