E-ISSN 2367-699X | ISSN 2367-7414
 

Review Article 


Effect of HPV status, smoking and alcohol consumption, on miRNA expression in oral cancer - a review of the literature

Konstantin Tonchev, Boyan Vladimirov, Victoria Sarafian, Nikolai Mehterov.


Abstract
Oral squamous cell carcinoma (OSCC) is the most common cancer type arising in the oral cavity and belongs to the wider group of head and neck cancers (HNCs).MicroRNAs (miRNAs) in mature form are noncoding RNAs, that regulate posttranscriptional gene expression by relatively nonspecific binding.As a result a single miRNA may regulate/control the expression of several genes which are involved in a variety of cellular processes like regulation of cellular differentiation, proliferation and apoptosis thus playing a role in cancer development.The AIM of this review was to summarize current findings on the effect of HPV status and presence of risk factors - smoking and alcohol consumption on miRNA expression as cancer biomarkers in patients with OSCC.

Key words: oral cancer OSCC miRNA expression HPV smoking alcohol


 
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How to Cite this Article
Pubmed Style

Konstantin Tonchev, Boyan Vladimirov, Victoria Sarafian, Nikolai Mehterov. Effect of HPV status, smoking and alcohol consumption, on miRNA expression in oral cancer - a review of the literature. Int J Surg Med. 2017; 3(4): 234-243. doi:10.5455/ijsm.mirna-expression-in-oral-cancer


Web Style

Konstantin Tonchev, Boyan Vladimirov, Victoria Sarafian, Nikolai Mehterov. Effect of HPV status, smoking and alcohol consumption, on miRNA expression in oral cancer - a review of the literature. https://www.ejos.org/?mno=277072 [Access: February 21, 2024]. doi:10.5455/ijsm.mirna-expression-in-oral-cancer


AMA (American Medical Association) Style

Konstantin Tonchev, Boyan Vladimirov, Victoria Sarafian, Nikolai Mehterov. Effect of HPV status, smoking and alcohol consumption, on miRNA expression in oral cancer - a review of the literature. Int J Surg Med. 2017; 3(4): 234-243. doi:10.5455/ijsm.mirna-expression-in-oral-cancer



Vancouver/ICMJE Style

Konstantin Tonchev, Boyan Vladimirov, Victoria Sarafian, Nikolai Mehterov. Effect of HPV status, smoking and alcohol consumption, on miRNA expression in oral cancer - a review of the literature. Int J Surg Med. (2017), [cited February 21, 2024]; 3(4): 234-243. doi:10.5455/ijsm.mirna-expression-in-oral-cancer



Harvard Style

Konstantin Tonchev, Boyan Vladimirov, Victoria Sarafian, Nikolai Mehterov (2017) Effect of HPV status, smoking and alcohol consumption, on miRNA expression in oral cancer - a review of the literature. Int J Surg Med, 3 (4), 234-243. doi:10.5455/ijsm.mirna-expression-in-oral-cancer



Turabian Style

Konstantin Tonchev, Boyan Vladimirov, Victoria Sarafian, Nikolai Mehterov. 2017. Effect of HPV status, smoking and alcohol consumption, on miRNA expression in oral cancer - a review of the literature. International Journal of Surgery and Medicine, 3 (4), 234-243. doi:10.5455/ijsm.mirna-expression-in-oral-cancer



Chicago Style

Konstantin Tonchev, Boyan Vladimirov, Victoria Sarafian, Nikolai Mehterov. "Effect of HPV status, smoking and alcohol consumption, on miRNA expression in oral cancer - a review of the literature." International Journal of Surgery and Medicine 3 (2017), 234-243. doi:10.5455/ijsm.mirna-expression-in-oral-cancer



MLA (The Modern Language Association) Style

Konstantin Tonchev, Boyan Vladimirov, Victoria Sarafian, Nikolai Mehterov. "Effect of HPV status, smoking and alcohol consumption, on miRNA expression in oral cancer - a review of the literature." International Journal of Surgery and Medicine 3.4 (2017), 234-243. Print. doi:10.5455/ijsm.mirna-expression-in-oral-cancer



APA (American Psychological Association) Style

Konstantin Tonchev, Boyan Vladimirov, Victoria Sarafian, Nikolai Mehterov (2017) Effect of HPV status, smoking and alcohol consumption, on miRNA expression in oral cancer - a review of the literature. International Journal of Surgery and Medicine, 3 (4), 234-243. doi:10.5455/ijsm.mirna-expression-in-oral-cancer