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Online Published: 30 Apr 2018
 


STEREOLOGICAL STUDY OF COLLAGEN IN THE AGING OF URINARY BLADDER IN RATS

Marcelo Zeni, Eduardo Felippe Melchioretto, Djanira Aparecida Da Luz Veronez, Emerson Keiji Nakamura, Gustavo Leonel Ferreira, Rogerio De Fraga.


Abstract
BACKGROUND: The aging process is inevitable and culminates in functional worsening of multiple systems, including the urinary bladder. Functional alterations of the bladder are recognized, as well as the importance of connective tissue and collagen to normal bladder functions. However, little is known about which are the structural alterations suffered by bladder in the aging process.
PURPOSE: To describe and to quantify histological alterations related to collagen types I and III through stereology in rats submitted to the process of aging urinary bladder.
METHODS: Seventy-two Wistar rats were divided in six groups. Each group was sacrificed in different ages: 3, 6, 9, 12, 18 and 24 months. It was removed the urinary bladder and performed stereological and histological analysis of the bladder tissue’s collagen (volumetric density of collagen types I and III, and their relative frequencies).
RESULTS: Between groups 1 (3 months) and 2 (6 months) there was a statistically significant increase in collagen type III. When compared groups of younger rats (3-12 months) to older rats (18-24 months), a significant decrease of volumetric density of collagen type III (p <0.05) is noticed. As for collagen type I, the highest relative frequency occurred at 12 months and suffered a decrease in the older groups 5 and 6 (p <0.05).
CONCLUSIONS: There are significant alterations in volumetric densities of collagen types I and III with the aging of the urinary bladder. We observed a decrease in volumetric density of collagen type III when compared younger to older rats.

Key words: Aging, Urinary Bladder, Histology, Rats


 
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How to Cite this Article
Pubmed Style

Zeni M, Melchioretto EF, Veronez DADL, Nakamura EK, Ferreira GL, Fraga RD. STEREOLOGICAL STUDY OF COLLAGEN IN THE AGING OF URINARY BLADDER IN RATS. Int J Surg Med. 2018; 4(2): 78-84. doi:10.5455/ijsm.COLLAGEN-IN-THE-AGEING-OF-URINARY-BLADDER-IN-RATS

Web Style

Zeni M, Melchioretto EF, Veronez DADL, Nakamura EK, Ferreira GL, Fraga RD. STEREOLOGICAL STUDY OF COLLAGEN IN THE AGING OF URINARY BLADDER IN RATS. https://www.ejos.org/?mno=281095 [Access: June 22, 2026]. doi:10.5455/ijsm.COLLAGEN-IN-THE-AGEING-OF-URINARY-BLADDER-IN-RATS

AMA (American Medical Association) Style

Zeni M, Melchioretto EF, Veronez DADL, Nakamura EK, Ferreira GL, Fraga RD. STEREOLOGICAL STUDY OF COLLAGEN IN THE AGING OF URINARY BLADDER IN RATS. Int J Surg Med. 2018; 4(2): 78-84. doi:10.5455/ijsm.COLLAGEN-IN-THE-AGEING-OF-URINARY-BLADDER-IN-RATS


Vancouver/ICMJE Style

Zeni M, Melchioretto EF, Veronez DADL, Nakamura EK, Ferreira GL, Fraga RD. STEREOLOGICAL STUDY OF COLLAGEN IN THE AGING OF URINARY BLADDER IN RATS. Int J Surg Med. (2018), [cited June 22, 2026]; 4(2): 78-84. doi:10.5455/ijsm.COLLAGEN-IN-THE-AGEING-OF-URINARY-BLADDER-IN-RATS


Harvard Style

Zeni, M., Melchioretto, . E. F., Veronez, . D. A. D. L., Nakamura, . E. K., Ferreira, . G. L. & Fraga, . R. D. (2018) STEREOLOGICAL STUDY OF COLLAGEN IN THE AGING OF URINARY BLADDER IN RATS. Int J Surg Med, 4 (2), 78-84. doi:10.5455/ijsm.COLLAGEN-IN-THE-AGEING-OF-URINARY-BLADDER-IN-RATS


Turabian Style

Zeni, Marcelo, Eduardo Felippe Melchioretto, Djanira Aparecida Da Luz Veronez, Emerson Keiji Nakamura, Gustavo Leonel Ferreira, and Rogerio De Fraga. 2018. STEREOLOGICAL STUDY OF COLLAGEN IN THE AGING OF URINARY BLADDER IN RATS. International Journal of Surgery and Medicine, 4 (2), 78-84. doi:10.5455/ijsm.COLLAGEN-IN-THE-AGEING-OF-URINARY-BLADDER-IN-RATS


Chicago Style

Zeni, Marcelo, Eduardo Felippe Melchioretto, Djanira Aparecida Da Luz Veronez, Emerson Keiji Nakamura, Gustavo Leonel Ferreira, and Rogerio De Fraga. "STEREOLOGICAL STUDY OF COLLAGEN IN THE AGING OF URINARY BLADDER IN RATS." International Journal of Surgery and Medicine 4 (2018), 78-84. doi:10.5455/ijsm.COLLAGEN-IN-THE-AGEING-OF-URINARY-BLADDER-IN-RATS


MLA (The Modern Language Association) Style

Zeni, Marcelo, Eduardo Felippe Melchioretto, Djanira Aparecida Da Luz Veronez, Emerson Keiji Nakamura, Gustavo Leonel Ferreira, and Rogerio De Fraga. "STEREOLOGICAL STUDY OF COLLAGEN IN THE AGING OF URINARY BLADDER IN RATS." International Journal of Surgery and Medicine 4.2 (2018), 78-84. Print. doi:10.5455/ijsm.COLLAGEN-IN-THE-AGEING-OF-URINARY-BLADDER-IN-RATS


APA (American Psychological Association) Style

Zeni, M., Melchioretto, . E. F., Veronez, . D. A. D. L., Nakamura, . E. K., Ferreira, . G. L. & Fraga, . R. D. (2018) STEREOLOGICAL STUDY OF COLLAGEN IN THE AGING OF URINARY BLADDER IN RATS. International Journal of Surgery and Medicine, 4 (2), 78-84. doi:10.5455/ijsm.COLLAGEN-IN-THE-AGEING-OF-URINARY-BLADDER-IN-RATS


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