E-ISSN 2367-699X | ISSN 2367-7414
 

Review Article 


The Mystery of Hypoxia in COVID-19

Varsha Konyala, Raghavendra Bhat.

Abstract
The COVID-19 pandemic has caused untimely deaths of many people.Predominantly, many of those who have been infected, have had an uneventful recovery.However, for those with co-morbidities, advanced ages, the story has been different. This review aims to highlight various pathogenesis of SARS-CoV-2 through the lens of hypoxia.The review consolidates information about virus induced hypoxia, neuroinvasive cause of hypoxia, thromboembolic cause of hypoxia, bradykinin and cytokine storms contributing to hypoxia.It brings out aspects of immune response which is aided by both coagulation cascade and the complement.In conclusion, we suggest care providers to be on the look out for asymptomatic hypoxia. We implore physicians and researchers to revisit and acutely look at the behaviour of the virus in vivo and the resulting immune response to be well equipped in this fight against the SARS-CoV-2 virus.

Key words: Happy hypoxia, Cytokine storm, Bradykinin storm, Neuroinvasive SARS-CoV-2, SARS-CoV-2, COVID-19


 
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How to Cite this Article
Pubmed Style

Konyala V, Bhat R, . The Mystery of Hypoxia in COVID-19. Int J Surg Med. 2020; 6(6): 85-94. doi:10.5455/ijsm.Mystery-Hypoxia-COVID-19


Web Style

Konyala V, Bhat R, . The Mystery of Hypoxia in COVID-19. http://www.ejos.org/?mno=3442 [Access: December 25, 2020]. doi:10.5455/ijsm.Mystery-Hypoxia-COVID-19


AMA (American Medical Association) Style

Konyala V, Bhat R, . The Mystery of Hypoxia in COVID-19. Int J Surg Med. 2020; 6(6): 85-94. doi:10.5455/ijsm.Mystery-Hypoxia-COVID-19



Vancouver/ICMJE Style

Konyala V, Bhat R, . The Mystery of Hypoxia in COVID-19. Int J Surg Med. (2020), [cited December 25, 2020]; 6(6): 85-94. doi:10.5455/ijsm.Mystery-Hypoxia-COVID-19



Harvard Style

Konyala, V., Bhat, R. & (2020) The Mystery of Hypoxia in COVID-19. Int J Surg Med, 6 (6), 85-94. doi:10.5455/ijsm.Mystery-Hypoxia-COVID-19



Turabian Style

Konyala, Varsha, Raghavendra Bhat, and . 2020. The Mystery of Hypoxia in COVID-19. International Journal of Surgery and Medicine, 6 (6), 85-94. doi:10.5455/ijsm.Mystery-Hypoxia-COVID-19



Chicago Style

Konyala, Varsha, Raghavendra Bhat, and . "The Mystery of Hypoxia in COVID-19." International Journal of Surgery and Medicine 6 (2020), 85-94. doi:10.5455/ijsm.Mystery-Hypoxia-COVID-19



MLA (The Modern Language Association) Style

Konyala, Varsha, Raghavendra Bhat, and . "The Mystery of Hypoxia in COVID-19." International Journal of Surgery and Medicine 6.6 (2020), 85-94. Print. doi:10.5455/ijsm.Mystery-Hypoxia-COVID-19



APA (American Psychological Association) Style

Konyala, V., Bhat, R. & (2020) The Mystery of Hypoxia in COVID-19. International Journal of Surgery and Medicine, 6 (6), 85-94. doi:10.5455/ijsm.Mystery-Hypoxia-COVID-19