E-ISSN 2367-699X | ISSN 2367-7414
 

Original Research 


CHANGES IN SERUM LEVELS OF IL-6 IN THE EARLY POSTOPERATIVE PERIOD AFTER PREEMPTIVE ANALGESIA WITH NIMESULIDE, METAMIZOLE SODIUM AND PLACEBO IN REMOVAL OF IMPACTED MANDIBULAR THIRD MOLARS

Deyan Zdravkov Neychev, Irina Stanimirova, Kiril Kostov Simitchiev, Mariana Murdjeva, Dimitar Atanasov.

Abstract
Objective: The objective of this study is to determine the change in IL-6 serum levels in patients undergoing preemptive analgesia and surgical removal of an impacted mandibular third molar.
Study Design: This is a prospective, double-blind, placebo-controlled study in 80 patients who had an atypical extraction of an impacted mandibular third molar.
Results: After surgical removal of impacted mandibular third molars, elevated levels of IL-6 in the early postoperative period were found, and the highest level was 14 pg/ml.
Conclusion: Postoperative IL-6 levels rise regardless of the medication used for preemptive analgesia. In the group treated with nimesulide, a trend to reducing IL-6 levels was observed, but further study in a larger number of patients is needed.

Key words: interleukin-6, preemptive analgesia, third molar surgery


 
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How to Cite this Article
Pubmed Style

Deyan Zdravkov Neychev, Irina Stanimirova, Kiril Kostov Simitchiev, Mariana Murdjeva, Dimitar Atanasov. CHANGES IN SERUM LEVELS OF IL-6 IN THE EARLY POSTOPERATIVE PERIOD AFTER PREEMPTIVE ANALGESIA WITH NIMESULIDE, METAMIZOLE SODIUM AND PLACEBO IN REMOVAL OF IMPACTED MANDIBULAR THIRD MOLARS. Int J Surg Med. 2016; 2(3): 111-116. doi:10.5455/ijsm.mandibular-third-molar


Web Style

Deyan Zdravkov Neychev, Irina Stanimirova, Kiril Kostov Simitchiev, Mariana Murdjeva, Dimitar Atanasov. CHANGES IN SERUM LEVELS OF IL-6 IN THE EARLY POSTOPERATIVE PERIOD AFTER PREEMPTIVE ANALGESIA WITH NIMESULIDE, METAMIZOLE SODIUM AND PLACEBO IN REMOVAL OF IMPACTED MANDIBULAR THIRD MOLARS. http://www.ejos.org/?mno=225611 [Access: November 03, 2020]. doi:10.5455/ijsm.mandibular-third-molar


AMA (American Medical Association) Style

Deyan Zdravkov Neychev, Irina Stanimirova, Kiril Kostov Simitchiev, Mariana Murdjeva, Dimitar Atanasov. CHANGES IN SERUM LEVELS OF IL-6 IN THE EARLY POSTOPERATIVE PERIOD AFTER PREEMPTIVE ANALGESIA WITH NIMESULIDE, METAMIZOLE SODIUM AND PLACEBO IN REMOVAL OF IMPACTED MANDIBULAR THIRD MOLARS. Int J Surg Med. 2016; 2(3): 111-116. doi:10.5455/ijsm.mandibular-third-molar



Vancouver/ICMJE Style

Deyan Zdravkov Neychev, Irina Stanimirova, Kiril Kostov Simitchiev, Mariana Murdjeva, Dimitar Atanasov. CHANGES IN SERUM LEVELS OF IL-6 IN THE EARLY POSTOPERATIVE PERIOD AFTER PREEMPTIVE ANALGESIA WITH NIMESULIDE, METAMIZOLE SODIUM AND PLACEBO IN REMOVAL OF IMPACTED MANDIBULAR THIRD MOLARS. Int J Surg Med. (2016), [cited November 03, 2020]; 2(3): 111-116. doi:10.5455/ijsm.mandibular-third-molar



Harvard Style

Deyan Zdravkov Neychev, Irina Stanimirova, Kiril Kostov Simitchiev, Mariana Murdjeva, Dimitar Atanasov (2016) CHANGES IN SERUM LEVELS OF IL-6 IN THE EARLY POSTOPERATIVE PERIOD AFTER PREEMPTIVE ANALGESIA WITH NIMESULIDE, METAMIZOLE SODIUM AND PLACEBO IN REMOVAL OF IMPACTED MANDIBULAR THIRD MOLARS. Int J Surg Med, 2 (3), 111-116. doi:10.5455/ijsm.mandibular-third-molar



Turabian Style

Deyan Zdravkov Neychev, Irina Stanimirova, Kiril Kostov Simitchiev, Mariana Murdjeva, Dimitar Atanasov. 2016. CHANGES IN SERUM LEVELS OF IL-6 IN THE EARLY POSTOPERATIVE PERIOD AFTER PREEMPTIVE ANALGESIA WITH NIMESULIDE, METAMIZOLE SODIUM AND PLACEBO IN REMOVAL OF IMPACTED MANDIBULAR THIRD MOLARS. International Journal of Surgery and Medicine, 2 (3), 111-116. doi:10.5455/ijsm.mandibular-third-molar



Chicago Style

Deyan Zdravkov Neychev, Irina Stanimirova, Kiril Kostov Simitchiev, Mariana Murdjeva, Dimitar Atanasov. "CHANGES IN SERUM LEVELS OF IL-6 IN THE EARLY POSTOPERATIVE PERIOD AFTER PREEMPTIVE ANALGESIA WITH NIMESULIDE, METAMIZOLE SODIUM AND PLACEBO IN REMOVAL OF IMPACTED MANDIBULAR THIRD MOLARS." International Journal of Surgery and Medicine 2 (2016), 111-116. doi:10.5455/ijsm.mandibular-third-molar



MLA (The Modern Language Association) Style

Deyan Zdravkov Neychev, Irina Stanimirova, Kiril Kostov Simitchiev, Mariana Murdjeva, Dimitar Atanasov. "CHANGES IN SERUM LEVELS OF IL-6 IN THE EARLY POSTOPERATIVE PERIOD AFTER PREEMPTIVE ANALGESIA WITH NIMESULIDE, METAMIZOLE SODIUM AND PLACEBO IN REMOVAL OF IMPACTED MANDIBULAR THIRD MOLARS." International Journal of Surgery and Medicine 2.3 (2016), 111-116. Print. doi:10.5455/ijsm.mandibular-third-molar



APA (American Psychological Association) Style

Deyan Zdravkov Neychev, Irina Stanimirova, Kiril Kostov Simitchiev, Mariana Murdjeva, Dimitar Atanasov (2016) CHANGES IN SERUM LEVELS OF IL-6 IN THE EARLY POSTOPERATIVE PERIOD AFTER PREEMPTIVE ANALGESIA WITH NIMESULIDE, METAMIZOLE SODIUM AND PLACEBO IN REMOVAL OF IMPACTED MANDIBULAR THIRD MOLARS. International Journal of Surgery and Medicine, 2 (3), 111-116. doi:10.5455/ijsm.mandibular-third-molar